Z411604
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Z411604
Aldrich
Combinatorial Chemistry and Molecular Diversity in Drug Discovery
| ISBN-10: | 0471155187 |
| ISBN-13: | 978-047115518-8 |
Description
| General description | This book highlights the critical concepts and issues involved in implementing combinatorial chemistry to create chemical libraries. It not only covers both the techniques and tools used in this field, but also the organizational and strategic questions faced by pharmaceutical managers. The authors apply combinatorial technologies to drug discovery and development and place co-evolving technologies and practices in a global framework. Included among the many topics are Library strategy and design; Solid-phase synthesis; Small molecular libraries; Automation, analytical, and computational methodology; Biological diversity; Strategies for screening combinatorial libraries; Combinatorial drug screening and development. |
Properties
| publication info | E. Gordon, ed., John Wiley & Sons, Ltd, 1998, 516 pp., hard cover |
Table Of Contents
| Table of Contents | PARTIAL TABLE OF CONTENTS: COMBINATORIAL CHEMISTRY AND MOLECULAR DIVERSITY: AN INTRODUCTION. Historical Overview of the Developing Field of Molecular Diversity Solid-Phase Peptide Synthesis, Lead Generation, and Optimization Oligonucleotide Libraries as a Source of Molecular Diversity SMALL MOLECULAR LIBRARIES. Protease Inhibitor Libraries . Scaffolds for Small Molecule Libraries Encoded Combinatorial Chemistry Parallel Organic Synthesis in Array Format AUTOMATION, ANALYTICAL, AND COMPUTATIONAL METHODS. Automation of Combinatorial Chemistry for Large Libraries Quantifying Diversity BIOLOGICAL DIVERSITY. Protein Scaffolds for Peptide Libraries SCREENING. Strategies for Screening Combinatorial Libraries COMBINATORIAL DRUG SCREENING AND DEVELOPMENT. Combinatorial Technologies: Prospects and Future Issues Appendix. Index. |
